Name: Rp-dGTPαS
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT218832670
Cas No:
Common Name:Rp-dGTPαS
alias:Rp-dGTP-α-S
IUPAC:({[({[5-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(sulfanyl)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
IUPAC:({[({[5-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(sulfanyl)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
InChI key:IOCRYHATDKHWPM-UHFFFAOYSA-N

Molecular Formula:C10H16N5O12P3S
Molecular Weight:523.24
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Nc1nc(=O)c2ncn(C3CC(O)C(COP(S)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2[nH]1
SMILES:Nc1nc(=O)c2ncn(C3CC(O)C(COP(S)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2[nH]1

Rp-dGTPαS, an enantiomer of the dNTPαS nucleotide, serves as the substrate for SAMHD1, a critical regulator of cellular dNTP levels that curtails the replication of viruses (HIV-1, etc.) in CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex facilitates the hydrolysis of Rp-dGQTPαS into 2'-deoxynucleosides and triphosphates [1].

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~