Name: CoPoP
Rating: 4 (6 reviews)

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Molecular Formula:C57H80CoN5O9P
Molecular Weight:1069.2
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC1C(C)C2=[N]3C1=C1CC(=O)C4=C1[N-]1C(C=C5C(CC)=C(C)C6=[N]5[Co++]31[N-]1C(=C2)C(C)=C(C=C)C1=C6)=C4C
SMILES:CCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC1C(C)C2=[N]3C1=C1CC(=O)C4=C1[N-]1C(C=C5C(CC)=C(C)C6=[N]5[Co++]31[N-]1C(=C2)C(C)=C(C=C)C1=C6)=C4C

CoPoP is a cobalt porphyrin-phospholipid liposome platform designed for multivalent antigen display. It enables stable, non-covalent docking of His-tagged proteins, achieving high-density surface decoration with up to 2000-fold higher antibody titers in mice compared to soluble antigen alone. When combined with QS-21 adjuvant, CoPoP formulations elicit Th1-biased CD4+ and CD8+ T-cell IFN-γ responses and functional neutralizing antibodies, with protection observed in lethal challenge models. This system is widely used in vaccine research for infectious diseases requiring robust humoral and cellular immunity.

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