Name: PLK4-IN-4
Rating: 4 (6 reviews)

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HIT ID:HIT218832686
Cas No:
Common Name:PLK4-IN-4
IUPAC:N6-[(2,4-difluorophenyl)methyl]-N4-(5-methyl-1H-pyrazol-3-yl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
IUPAC:N6-[(2,4-difluorophenyl)methyl]-N4-(5-methyl-1H-pyrazol-3-yl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
InChIKey:HPYJNDCKRXOAKV-UHFFFAOYSA-N

Molecular Formula:C21H23F2N9
Molecular Weight:439.475
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3n(ncc23)C2CCNCC2)n[nH]1
SMILES:Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3n(ncc23)C2CCNCC2)n[nH]1

PLK4-IN-4 (compound 22), a potent inhibitor of PLK4, exhibits an IC₅₀ value of 7.9 nM, suggesting its potential use in cancer research ^[1].

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