Name: (R)-IDO/TDO-IN-1
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HIT ID:HIT218832697
Cas No:
Common Name:(R)-IDO/TDO-IN-1
IUPAC:4-{6-fluoro-5H-imidazo[4,3-a]isoindol-5-yl}-1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]piperidine
IUPAC:4-{6-fluoro-5H-imidazo[4,3-a]isoindol-5-yl}-1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]piperidine
InChIKey:UJGQDAMZVUNFBQ-UHFFFAOYSA-N

Molecular Formula:C25H24FN5
Molecular Weight:413.5
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cn1cc(cn1)-c1ccc(cc1)N1CCC(CC1)C1c2c(cccc2F)-c2cncn12
SMILES:Cn1cc(cn1)-c1ccc(cc1)N1CCC(CC1)C1c2c(cccc2F)-c2cncn12

(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].

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