Name: LU-005i
Rating: 4 (6 reviews)

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HIT ID:HIT218832705
Cas No:
Common Name:LU-005i
IUPAC:N-[3-cyclohexyl-1-(2-methyloxiran-2-yl)-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-{2-[2-(morpholin-4-yl)acetamido]propanamido}propanamide
IUPAC:N-[3-cyclohexyl-1-(2-methyloxiran-2-yl)-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-{2-[2-(morpholin-4-yl)acetamido]propanamido}propanamide
InChIKey:UHNYITHLNFUAIN-UHFFFAOYSA-N

Molecular Formula:C31H46N4O7
Molecular Weight:586.73
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COc1ccc(CC(NC(=O)C(C)NC(=O)CN2CCOCC2)C(=O)NC(CC2CCCCC2)C(=O)C2(C)CO2)cc1
SMILES:COc1ccc(CC(NC(=O)C(C)NC(=O)CN2CCOCC2)C(=O)NC(CC2CCCCC2)C(=O)C2(C)CO2)cc1

LU-005i is a powerful inhibitor targeting the β5i subunit of immunoproteasomes, displaying a high potency with an IC 50 value of 6.6 nM, and exhibits selectivity by preferring β5i over the β5c subunit, which has an IC 50 value of 287 nM [1].

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