Name: LNP Lipid-8
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HIT ID:HIT218832719
Cas No:
Common Name:LNP Lipid-8
IUPAC:3-{[2-(adamantan-1-yl)acetyl]oxy}-2-[({[3-(diethylamino)propoxy]carbonyl}oxy)methyl]propyl octadeca-9,12-dienoate
IUPAC:3-{[2-(adamantan-1-yl)acetyl]oxy}-2-[({[3-(diethylamino)propoxy]carbonyl}oxy)methyl]propyl octadeca-9,12-dienoate
InChIKey:FNGYOMDNOWZUBX-UHFFFAOYSA-N

Molecular Formula:C42H71NO7
Molecular Weight:702.03
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC=CCC=CCCCCCCCC(=O)OCC(COC(=O)CC12CC3CC(CC(C3)C1)C2)COC(=O)OCCCN(CC)CC
SMILES:CCCCCC=CCC=CCCCCCCCC(=O)OCC(COC(=O)CC12CC3CC(CC(C3)C1)C2)COC(=O)OCCCN(CC)CC

LNP Lipid-8 (11-A-M), an ionizable lipid, is utilized in lipid nanoparticles (LNP) for siRNA delivery to T cells without ligand targeting. When loaded with GFP siRNA (siGFP), it significantly silences the GFP gene in a mouse model [1].

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