Name: CL4F8-6
Rating: 4 (6 reviews)

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HIT ID:HIT218832722
Cas No:
Common Name:CL4F8-6
IUPAC:7-[4-(dipropylamino)butyl]-13-[(2-hexyloctanoyl)oxy]-7-hydroxytridecyl 2-hexyloctanoate
IUPAC:7-[4-(dipropylamino)butyl]-13-[(2-hexyloctanoyl)oxy]-7-hydroxytridecyl 2-hexyloctanoate
InChIKey:FIQJUNNYZXWQKM-UHFFFAOYSA-N

Molecular Formula:C51H101NO5
Molecular Weight:808.371
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCCC(CCCCCC)C(=O)OCCCCCCC(O)(CCCCCCOC(=O)C(CCCCCC)CCCCCC)CCCCN(CCC)CCC
SMILES:CCCCCCC(CCCCCC)C(=O)OCCCCCCC(O)(CCCCCCOC(=O)C(CCCCCC)CCCCCC)CCCCN(CCC)CCC

CL4F8-6, an ionizable cationic lipid with a pKa of 6.14, is utilized in lipid nanoparticles (LNPs) for mRNA therapeutics. When incorporated into LNPs delivering Cas9 mRNA and sgRNA, CL4F8-6 facilitates CRISPR-mediated gene knockdown in mice [1].

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