Name: Mahuannin B
Rating: 4 (6 reviews)

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HIT ID:HIT218832786
Cas No:
Common Name:Mahuannin B
IUPAC:5,13-bis(4-hydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0^{2,11}.0^{3,8}.0^{15,20}]henicosa-2(11),3(8),9,15,17,19-hexaene-6,9,17,19,21-pentol
IUPAC:5,13-bis(4-hydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0^{2,11}.0^{3,8}.0^{15,20}]henicosa-2(11),3(8),9,15,17,19-hexaene-6,9,17,19,21-pentol
InChIKey:LQRHGTVFFPMWCG-UHFFFAOYSA-N

Molecular Formula:C30H24O10
Molecular Weight:544.512
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:OC1Cc2c(O)cc3OC4(Oc5cc(O)cc(O)c5C(C4O)c3c2OC1c1ccc(O)cc1)c1ccc(O)cc1
SMILES:OC1Cc2c(O)cc3OC4(Oc5cc(O)cc(O)c5C(C4O)c3c2OC1c1ccc(O)cc1)c1ccc(O)cc1

Mahuannin B is a flavonoid derivative isolated from Ephedra Radix that functions as an adenylate cyclase inhibitor. It effectively suppresses sweating by blocking the β2-adrenoceptor/cAMP signaling pathway, reducing intracellular cAMP production by over 50% through direct inhibition of AC activity. This compound is valuable for research into eccrine gland function, hyperhidrosis models, and cAMP-dependent signal transduction pathways.

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