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- HIT ID:HIT218832819
- Cas No:
- Common Name:Thujopsene
- alias:NSC 44707
- InChIKey:WXQGPFZDVCRBME-UHFFFAOYSA-N
- Molecular Formula:C15H24
- Molecular Weight:204.357
- Hydrogen Bond Donor (HBD):
- Hydrogen Bond Acceptor (HBA):
- LogP:
- Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-sensitized RBL-2H3 mast cells (IC50= 25.1 µM) and shows cytotoxicity against A549 non-small cell lung cancer cells with an LC50 of 35.27 µg/ml. Furthermore, thujopsene causes mortality in mites D. farinae and T. putrescentiae, with LC50s of 9.82 and 10.92 µg/cm2, respectively.
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- SupplierTargetMolPack SizeEstimated Lead Time35 daysPurity-$ 195.001
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