Name: 1,1'-Ethylidene-bis-(L-tryptophan)
Rating: 5 (10 reviews)

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HIT ID:HIT218832827
Cas No:
常用名:1,1'-Ethylidene-bis-(L-tryptophan)
常用名:1,1'-Ethylidene-bis-(L-tryptophan)
别名:Peak 97 Contaminant
IUPAC:2-amino-3-(1-{1-[3-(2-amino-2-carboxyethyl)-1H-indol-1-yl]ethyl}-1H-indol-3-yl)propanoic acid
IUPAC:2-amino-3-(1-{1-[3-(2-amino-2-carboxyethyl)-1H-indol-1-yl]ethyl}-1H-indol-3-yl)propanoic acid
InChI key:DETVQFQGSVEQBH-UHFFFAOYSA-N

分子式:C24H26N4O4
分子量:434.496
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(n1cc(CC(N)C(O)=O)c2ccccc12)n1cc(CC(N)C(O)=O)c2ccccc12
SMILES:CC(n1cc(CC(N)C(O)=O)c2ccccc12)n1cc(CC(N)C(O)=O)c2ccccc12

1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human peripheral blood eosinophils, and boosting IL-5 production in human T cells. At 40 µg/kg, it triggers fascia thickening, mast cell infiltration, inflammation, and fibrosis in mouse superficial adipose and panniculus carnosus tissues, serving as an eosinophilia-myalgia syndrome research model.

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