购物车
0
有库存
sdf 文件
结构编辑
类似物检索
- HIT ID:HIT218832841
- Cas No:
- 常用名:Sphingosine (d16:1)
- 别名:D-erythro-Sphingosine C-16
- InChI key:BTUSGZZCQZACPT-UHFFFAOYSA-N
- 分子式:C16H33NO2
- 分子量:271.445
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- Sphingosine (d16:1), an unconventional sphingolipid, is synthesized through enzymatic reactions starting with the condensation of myristoyl-CoA and serine by serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), which shows a preference for myristoyl-CoA. This compound is found in minute quantities in its free form in human plasma and as a component of various plasma sphingolipids, such as sphingosine-1-phosphate, ceramides, sphingomyelins, and in brain cerebrosides, albeit at lower concentrations than the more common d18:1 sphingoid base. Sphingosine (d16:1) acts as an inhibitor of PKC in mixed micelle assays and diminishes superoxide production triggered by phorbol 12-myristate 13-acetate in isolated human neutrophils, as well as inhibiting the growth of CHO cells with IC50 values of 1 and 3.2 µM, respectively. Additionally, the concentration of sphingolipids containing sphingosine (d16:1) in the plasma is linked to the dietary consumption of saturated fatty acids and protein among ethnic Chinese populations.
市场产品/服务共显示1个结果
- 供应商TargetMol规格货期35日内发货纯度-¥ 539.001
寻找合适的化合物库
您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。
电话：400820-0310
合作：info@screeningcompound.com
技术支持：tech@screeningcompound.com
客服：service@screeningcompound.com
查看大图
正在加载 ~