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- HIT ID:HIT218832870
- Cas No:
- 常用名:14S(15R)-EET methyl ester
- InChI key:MQCWCUDQEBWUAM-UHFFFAOYSA-N
- 分子式:C21H34O3
- 分子量:334.5
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- 14S(15R)-EET methyl ester, an oxylipin derived from arachidonic acid through cytochrome P450 metabolism, demonstrates specific biological activities. It exhibits affinity for isolated guinea pig monocytes, evidenced by a competitive binding assay with a Ki value of 612.5 nM using [3H]14(15)-EET. This compound notably enhances the dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM), indicating potent vasodilatory effects. Unlike its isomer 14R(15S)-EET, 14S(15R)-EET methyl ester does not inhibit COX activity in enzyme assays or affect isolated platelets, highlighting its distinct functional profile.
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- 供应商TargetMol规格货期35日内发货纯度-¥ 1,960.001
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