Name: 17(R)-Resolvin D3
Rating: 5 (10 reviews)

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HIT ID:HIT218832884
Cas No:
常用名:17(R)-Resolvin D3
别名:AT-RvD3, Aspirin-triggered Resolvin D3, 17-epi-Resolvin D3, 17(R)-RvD3
别名:AT-RvD3, Aspirin-triggered Resolvin D3, 17-epi-Resolvin D3, 17(R)-RvD3
IUPAC:4,11,17-trihydroxydocosa-5,7,9,13,15,19-hexaenoic acid
IUPAC:4,11,17-trihydroxydocosa-5,7,9,13,15,19-hexaenoic acid
InChI key:QBTJOLCUKWLTIC-UHFFFAOYSA-N

分子式:C22H32O5
分子量:376.493
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCC=CCC(O)C=CC=CCC(O)C=CC=CC=CC(O)CCC(O)=O
SMILES:CCC=CCC(O)C=CC=CCC(O)C=CC=CC=CC(O)CCC(O)=O

17(R)-Resolvin D3 (17(R)-RvD3) is an aspirin-triggered epimer of resolvin D3, produced from docosahexaenoic acid (DHA) through the action of COX-2 in the presence of aspirin, via a 17(R)-hydroperoxy DHA (17(R)-HDHA) intermediary. Identified in mouse inflammatory exudates, 17(R)-RvD3 notably inhibits the transmigration of isolated human polymorphonuclear cells (PMNs) and fosters the efferocytosis of apoptotic PMNs by macrophages. Furthermore, in a mouse model of zymosan-induced peritonitis, 17(R)-RvD3 administration (10 ng/animal) significantly curtails neutrophil infiltration into the peritoneal cavity and modulates cytokine levels by reducing IL-6 and increasing IL-10 in the inflammatory exudate. It engages GPR32, evidenced by activation in a β-arrestin reporter assay and augments phagocytosis more effectively in CHO cells overexpressing GPR32 compared to controls. Additionally, 17(R)-RvD3 enhances the clearance of etoposide-induced tumor cell debris by monocyte-derived macrophages in H460 human lung carcinoma.

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