Name: (−)-Voacangarine
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT218832893
Cas No:
Common Name:(−)-Voacangarine
alias:NSC 306219, (−)-Voacristine
IUPAC:methyl 17-(1-hydroxyethyl)-7-methoxy-3,13-diazapentacyclo[13.3.1.0^{2,10}.0^{4,9}.0^{13,18}]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
IUPAC:methyl 17-(1-hydroxyethyl)-7-methoxy-3,13-diazapentacyclo[13.3.1.0^{2,10}.0^{4,9}.0^{13,18}]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
InChIKey:OYMQKBZMKFJPMH-UHFFFAOYSA-N

Molecular Formula:C22H28N2O4
Molecular Weight:384.476
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COC(=O)C12CC3CC(C(C)O)C1N(C3)CCc1c2[nH]c2ccc(OC)cc12
SMILES:COC(=O)C12CC3CC(C(C)O)C1N(C3)CCc1c2[nH]c2ccc(OC)cc12

(–)-Voacangarine, an indole alkaloid isolated from V. africana, exhibits cytotoxicity towards various cell lines including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC₅₀ values of 20 µg/ml. Additionally, it demonstrates cytostatic effects on wild-type S. cerevisiae and is cytotoxic to Δrad3-e5 and Δrad6-1 mutant strains of S. cerevisiae, which have defects in DNA strand break repair and the mutagenic repair pathway, respectively.

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~