Name: 18-hydroxy-11-deoxy Corticosterone
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HIT ID:HIT218832900
Cas No:
Common Name:18-hydroxy-11-deoxy Corticosterone
Common Name:18-hydroxy-11-deoxy Corticosterone
alias:18-OH-DOC, 18-Hydroxydeoxycorticosterone
alias:18-OH-DOC, 18-Hydroxydeoxycorticosterone
IUPAC:1-(2-hydroxyacetyl)-11a-(hydroxymethyl)-9a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
IUPAC:1-(2-hydroxyacetyl)-11a-(hydroxymethyl)-9a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
InChIKey:VPJHREHKRNIYDB-UHFFFAOYSA-N

Molecular Formula:C21H30O4
Molecular Weight:346.467
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC12CCC(=O)C=C1CCC1C3CCC(C(=O)CO)C3(CO)CCC21
SMILES:CC12CCC(=O)C=C1CCC1C3CCC(C(=O)CO)C3(CO)CCC21

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

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