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  3. HIT218832902
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HIT218832902
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HIT218832902
  • HIT ID:HIT218832902
  • Cas No:
  • 常用名:GGTI 2133 TFA
  • IUPAC:2-[(4-{[(1H-imidazol-5-yl)methyl]amino}-2-(naphthalen-1-yl)phenyl)formamido]-4-methylpentanoic acid; trifluoroacetic acid
    IUPAC:2-[(4-{[(1H-imidazol-5-yl)methyl]amino}-2-(naphthalen-1-yl)phenyl)formamido]-4-methylpentanoic acid; trifluoroacetic acid
  • InChI key:FXXUNOYBYJFSRB-UHFFFAOYSA-N
  • 分子式:C29H29F3N4O5
  • 分子量:570.569
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)C(F)(F)F.CC(C)CC(NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O
    SMILES:OC(=O)C(F)(F)F.CC(C)CC(NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O
  • GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the farnesylation of H-Ras (IC50= >30 µM). Moreover, GGTI 2133 reduces the growth, migration, and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control levels, respectively. When administered intraperitoneally at 5 mg/kg per day, it prevents eosinophil infiltration into the airways in a mouse model of allergic bronchial asthma, although it does not reduce chemokine levels. Additionally, GGTI 2133 thwarts naloxone-induced contraction of ileum in rats experiencing morphine withdrawal syndrome and mitigates the severity of withdrawal symptoms in vivo (ED50= 0.076 mg/kg).
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,720.00
    1

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