N-Deacetylcolchicine | NSC 201400 | AnyMole

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HIT218832907

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HIT218832907

HIT ID:HIT218832907
Cas No:
常用名:N-Deacetylcolchicine
别名:NSC 201400
IUPAC:10-amino-3,4,5,14-tetramethoxytricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
IUPAC:10-amino-3,4,5,14-tetramethoxytricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
InChI key:HFPMXDMZJUJZBX-UHFFFAOYSA-N

分子式:C20H23NO5
分子量:357.406
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2CCC(N)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
SMILES:COc1cc2CCC(N)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC

Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.

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TargetMolSC
规格
货期
35日内发货
纯度
-
¥ 539.00
1

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