Name: Bostrycin
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HIT ID:HIT218832908
Cas No:
Common Name:Bostrycin
alias:Rhodosporin
IUPAC:5,6,7,9,10-pentahydroxy-2-methoxy-7-methyl-1,4,5,6,7,8-hexahydroanthracene-1,4-dione
IUPAC:5,6,7,9,10-pentahydroxy-2-methoxy-7-methyl-1,4,5,6,7,8-hexahydroanthracene-1,4-dione
InChIKey:ZQNOLGRKZRDRQO-UHFFFAOYSA-N

Molecular Formula:C16H16O8
Molecular Weight:336.296
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COC1=CC(=O)c2c(O)c3C(O)C(O)C(C)(O)Cc3c(O)c2C1=O
SMILES:COC1=CC(=O)c2c(O)c3C(O)C(O)C(C)(O)Cc3c(O)c2C1=O

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

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