Name: 7-keto-25-hydroxy Cholesterol
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HIT ID:HIT218832921
Cas No:
Common Name:7-keto-25-hydroxy Cholesterol
IUPAC:7-hydroxy-1-(6-hydroxy-6-methylheptan-2-yl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-one
IUPAC:7-hydroxy-1-(6-hydroxy-6-methylheptan-2-yl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-one
InChIKey:NQBVGGWSAXBLBE-UHFFFAOYSA-N

Molecular Formula:C27H44O3
Molecular Weight:416.646
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC(CCCC(C)(C)O)C1CCC2C3C(CCC12C)C1(C)CCC(O)CC1=CC3=O
SMILES:CC(CCCC(C)(C)O)C1CCC2C3C(CCC12C)C1(C)CCC(O)CC1=CC3=O

7-Keto-25-hydroxy Cholesterol, an oxysterol and proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol, binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. Additionally, it enhances the number of EGF high affinity binding sites in normal rat kidney (NRK) cells.

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