Name: (S)-3'-amino Blebbistatin
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT218832924
Cas No:
Common Name:(S)-3'-amino Blebbistatin
alias:meta-amino Blebbistatin, m-amino Blebbistatin, (−)-3'-amino Blebbistatin
alias:meta-amino Blebbistatin, m-amino Blebbistatin, (−)-3'-amino Blebbistatin
IUPAC:1-(3-aminophenyl)-3a-hydroxy-6-methyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
IUPAC:1-(3-aminophenyl)-3a-hydroxy-6-methyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
InChIKey:WWBDMJMBRYIBAY-UHFFFAOYSA-N

Molecular Formula:C18H17N3O2
Molecular Weight:307.353
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c1cccc(N)c1
SMILES:Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c1cccc(N)c1

"(S)-3'-amino Blebbistatin, retaining the active stereochemistry of the less stable and more phototoxic (–)-blebbistatin, serves as a refined selective cell-permeable inhibitor of non-muscle myosin II ATPases. This compound efficaciously inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across several species with IC₅₀s ranging from 0.5-5 µM, and exhibits minimal inhibition against smooth muscle myosin (IC₅₀= 80 µM). Its primary functions include obstructing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. (S)-3'-amino Blebbistatin overcomes (–)-blebbistatin's limitation of rapid degradation under blue light (450-490 nm) exposure, which generates cytotoxic intermediates, thus posing a challenge for fluorescent live cell imaging applications. The introduction of a 3'-amino group to its structure notably reduces fluorescence while maintaining (–)-blebbistatin's activity, making it a superior alternative for research purposes."

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~