Name: Salvinorin A Carbamate
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HIT ID:HIT218832934
Cas No:
Common Name:Salvinorin A Carbamate
alias:Sal A Carbamate, Divinorin A Carbamate
IUPAC:methyl 9-(carbamoyloxy)-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-dodecahydro-1H-naphtho[2,1-c]pyran-7-carboxylate
IUPAC:methyl 9-(carbamoyloxy)-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-dodecahydro-1H-naphtho[2,1-c]pyran-7-carboxylate
InChIKey:FHTGZEVOZWRYEL-UHFFFAOYSA-N

Molecular Formula:C22H27NO8
Molecular Weight:433.457
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COC(=O)C1CC(OC(N)=O)C(=O)C2C1(C)CCC1C(=O)OC(CC21C)c1ccoc1
SMILES:COC(=O)C1CC(OC(N)=O)C(=O)C2C1(C)CCC1C(=O)OC(CC21C)c1ccoc1

Salvinorin A carbamate, a potent κ-opioid receptor (KOR) full agonist, exhibits nearly the same potency as salvinorin A, with EC50 values of 6.2 and 4.5 nM, respectively, for activating the human KOR to augment the binding of [35S]GTPγS. Enhancing biological stability, the addition of a carbamate group to salvinorin A reduces deacetylation.

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