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HIT218832942
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HIT218832942
  • HIT ID:HIT218832942
  • Cas No:
  • Common Name:3-Aminoisobutyric Acid sodium
  • alias:β-Aminoisobutyric Acid, BAIBA
  • IUPAC:sodium 3-amino-2-methylpropanoate
    IUPAC:sodium 3-amino-2-methylpropanoate
  • InChIKey:JHRHAWUQGZVIRP-UHFFFAOYSA-M
  • Molecular Formula:C4H8NNaO2
  • Molecular Weight:125.103
  • Hydrogen Bond Donor (HBD):
  • Hydrogen Bond Acceptor (HBA):
  • LogP:
  • SMILES:[Na+].CC(CN)C([O-])=O
    SMILES:[Na+].CC(CN)C([O-])=O
  • 3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its administration at 100 mg/kg daily curtails weight gain and body fat without diminishing food consumption or hiking energy output, whilst ameliorating glucose tolerance. Notably, 3-aminoisobutyric acid concentrations are heightened in individuals with β-ureidopropionase deficiency, a genetic flaw impairing pyrimidine degradation, affecting plasma, urine, and cerebrospinal fluid.
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    TargetMolSC
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    35 days
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    $ 132.00
    1

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