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- HIT ID:HIT218832942
- Cas No:
- 常用名:3-Aminoisobutyric Acid sodium
- 别名:β-Aminoisobutyric Acid, BAIBA
- InChI key:JHRHAWUQGZVIRP-UHFFFAOYSA-M
- 分子式:C4H8NNaO2
- 分子量:125.103
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- 3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its administration at 100 mg/kg daily curtails weight gain and body fat without diminishing food consumption or hiking energy output, whilst ameliorating glucose tolerance. Notably, 3-aminoisobutyric acid concentrations are heightened in individuals with β-ureidopropionase deficiency, a genetic flaw impairing pyrimidine degradation, affecting plasma, urine, and cerebrospinal fluid.
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- 供应商TargetMol规格货期35日内发货纯度-¥ 945.001
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