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  3. HIT218832952
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HIT218832952
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HIT218832952
  • HIT ID:HIT218832952
  • Cas No:
  • 常用名:CPTH6 hydrobromide
  • IUPAC:4-(4-chlorophenyl)-2-[2-(3-methylcyclopentylidene)hydrazin-1-yl]-1,3-thiazole hydrobromide
    IUPAC:4-(4-chlorophenyl)-2-[2-(3-methylcyclopentylidene)hydrazin-1-yl]-1,3-thiazole hydrobromide
  • InChI key:FTEQRZOKSCOLKS-UHFFFAOYSA-N
  • 分子式:C15H17BrClN3S
  • 分子量:386.74
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Br.CC1CCC(C1)=NNc1nc(cs1)-c1ccc(Cl)cc1
    SMILES:Br.CC1CCC(C1)=NNc1nc(cs1)-c1ccc(Cl)cc1
  • CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    4-6周
    纯度
    -
    ¥ 7,000.00
    1

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