Name: CPTH6 hydrobromide
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HIT ID:HIT218832952
Cas No:
Common Name:CPTH6 hydrobromide
IUPAC:4-(4-chlorophenyl)-2-[2-(3-methylcyclopentylidene)hydrazin-1-yl]-1,3-thiazole hydrobromide
IUPAC:4-(4-chlorophenyl)-2-[2-(3-methylcyclopentylidene)hydrazin-1-yl]-1,3-thiazole hydrobromide
InChIKey:FTEQRZOKSCOLKS-UHFFFAOYSA-N

Molecular Formula:C15H17BrClN3S
Molecular Weight:386.74
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Br.CC1CCC(C1)=NNc1nc(cs1)-c1ccc(Cl)cc1
SMILES:Br.CC1CCC(C1)=NNc1nc(cs1)-c1ccc(Cl)cc1

CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.

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