Name: CCR4 antagonist 4
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

HIT ID:HIT218832961
Cas No:
Common Name:CCR4 antagonist 4
IUPAC:N-[(2,4-dichlorophenyl)methyl]-2-{4-[(2R)-piperidine-2-carbonyl]piperazin-1-yl}pyrido[2,3-d]pyrimidin-4-amine
IUPAC:N-[(2,4-dichlorophenyl)methyl]-2-{4-[(2R)-piperidine-2-carbonyl]piperazin-1-yl}pyrido[2,3-d]pyrimidin-4-amine
InChIKey:GDQQUDANFRCFMF-HXUWFJFHSA-N

Molecular Formula:C24H27Cl2N7O
Molecular Weight:500.43
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Clc1ccc(CNc2nc(nc3ncccc23)N2CCN(CC2)C(=O)[C@H]2CCCCN2)c(Cl)c1
SMILES:Clc1ccc(CNc2nc(nc3ncccc23)N2CCN(CC2)C(=O)[C@H]2CCCCN2)c(Cl)c1

CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC₅₀ value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC₅₀ values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~