Name: HPK1-IN-2 dihydrochloride
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HIT ID:HIT218832966
Cas No:
Common Name:HPK1-IN-2 dihydrochloride
IUPAC:4-amino-5-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-6H,7H-thieno[2,3-b]pyridin-6-one dihydrochloride
IUPAC:4-amino-5-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-6H,7H-thieno[2,3-b]pyridin-6-one dihydrochloride
InChIKey:XESGZTINOLHKPH-UHFFFAOYSA-N

Molecular Formula:C19H22Cl2N6OS
Molecular Weight:453.39
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cl.Cl.CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccsc2[nH]c1=O
SMILES:Cl.Cl.CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccsc2[nH]c1=O

HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].

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