Name: SOS1 agonist-1
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HIT ID:HIT218832969
Cas No:
Common Name:SOS1 agonist-1
IUPAC:tert-butyl 6-{4-bromo-6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-1,3-benzodiazol-2-yl}-2,6-diazaspiro[3.3]heptane-2-carboxylate
IUPAC:tert-butyl 6-{4-bromo-6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-1H-1,3-benzodiazol-2-yl}-2,6-diazaspiro[3.3]heptane-2-carboxylate
InChIKey:VXKBOSGNBGMADK-UHFFFAOYSA-N

Molecular Formula:C26H29BrClFN4O2
Molecular Weight:563.9
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cc1cc(Cn2c(nc3c(Br)cc(Cl)cc23)N2CC3(CN(C3)C(=O)OC(C)(C)C)C2)cc(C)c1F
SMILES:Cc1cc(Cn2c(nc3c(Br)cc(Cl)cc23)N2CC3(CN(C3)C(=O)OC(C)(C)C)C2)cc(C)c1F

SOS1 agonist-1 (compound 79) serves as an agonist for the Son of sevenless homologue 1 (SOS1), a crucial guanine nucleotide exchange factor involved in catalyzing the GDP to GTP exchange on RAS proteins, thus regulating RAS activation. By increasing nucleotide exchange on RAS, SOS1 agonists enhance cellular RAS-GTP levels and induce biphasic signaling alterations in ERK1/2 phosphorylation, playing a pivotal role in anti-cancer activity [1].

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