Name: Senexin A hydrochloride
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HIT ID:HIT218832980
Cas No:
Common Name:Senexin A hydrochloride
IUPAC:4-[(2-phenylethyl)amino]quinazoline-6-carbonitrile hydrochloride
IUPAC:4-[(2-phenylethyl)amino]quinazoline-6-carbonitrile hydrochloride
InChIKey:POENYXHGUHRXFR-UHFFFAOYSA-N

Molecular Formula:C17H15ClN4
Molecular Weight:310.79
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cl.N#Cc1ccc2ncnc(NCCc3ccccc3)c2c1
SMILES:Cl.N#Cc1ccc2ncnc(NCCc3ccccc3)c2c1

Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].

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