Name: GHK-Cu acetate
Rating: 5 (10 reviews)

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HIT ID:HIT218833001
Cas No:
常用名:GHK-Cu acetate
别名:Gly-His-Lys-Cu(II), Copper tripeptide acetate
别名:Gly-His-Lys-Cu(II), Copper tripeptide acetate
IUPAC:
IUPAC:
InChI key:JRNYINZVXMVTHX-ULEGLUPFSA-M

分子式:C16H24CuN6O6
分子量:459.95
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(O)=O.NCCCC[C@H](NC(=O)[C@@H]1CC2=CNC=[N]2[Cu++]2[N]CC(=O)[N-]12)C([O-])=O
SMILES:CC(O)=O.NCCCC[C@H](NC(=O)[C@@H]1CC2=CNC=[N]2[Cu++]2[N]CC(=O)[N-]12)C([O-])=O

GHK-Cu acetate, a complex of the tripeptide Gly-His-Lys and a copper(II) ion, exhibits wound healing and anti-inflammatory properties. It enhances fibroblast proliferation, collagen production, and the release of pro-matrix metalloproteinase-2 (MMP-2) and glycosaminoglycans (GAGs), while also increasing decorin expression in rat wound tissue. Furthermore, at a concentration of 10 µM, it reduces levels of reactive oxygen species (ROS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in LPS-stimulated RAW 264.7 cells. Additionally, GHK-Cu at 10 µg/g mitigates LPS-induced reductions in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels, decreases the accumulation of cells and total protein in bronchoalveolar lavage fluid (BALF), and thus, attenuates acute lung injury in mice.

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