Name: G-9807
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HIT ID:HIT218833011
Cas No:
Common Name:G-9807
alias:G9807, G 9807
IUPAC:6-[5-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-hydroxypiperidin-1-yl)-3,4-dihydropyrimidin-4-one
IUPAC:6-[5-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-hydroxypiperidin-1-yl)-3,4-dihydropyrimidin-4-one
InChIKey:CAASTELLWPCGBG-UHFFFAOYSA-N

Molecular Formula:C21H18F2N6O2
Molecular Weight:424.412
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:OC1CCN(CC1)c1nc(cc(=O)[nH]1)-c1n[nH]c2ncc(cc12)-c1c(F)cccc1F
SMILES:OC1CCN(CC1)c1nc(cc(=O)[nH]1)-c1n[nH]c2ncc(cc12)-c1c(F)cccc1F

G-9807 significantly increases the RNase activity of IRE1-KR-0P by stabilizing the active dimeric unit, which acts as a variable activator of RNase.

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