Name: Azalamellarin N
Rating: 5 (10 reviews)

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HIT ID:HIT218847506
Cas No:1809535-57-6
常用名:Azalamellarin N
别名:AZL-N
IUPAC:7,17-dihydroxy-12-(3-hydroxy-4-methoxyphenyl)-8,16-dimethoxy-1,4-diazapentacyclo[11.8.0.0^{2,11}.0^{5,10}.0^{14,19}]henicosa-2(11),5(10),6,8,12,14(19),15,17,20-nonaen-3-one
IUPAC:7,17-dihydroxy-12-(3-hydroxy-4-methoxyphenyl)-8,16-dimethoxy-1,4-diazapentacyclo[11.8.0.0^{2,11}.0^{5,10}.0^{14,19}]henicosa-2(11),5(10),6,8,12,14(19),15,17,20-nonaen-3-one
InChI key:NZFSEFXZZPPHMO-UHFFFAOYSA-N

分子式:C28H22N2O7
分子量:498.491
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(cc1O)-c1c2c(n3ccc4cc(O)c(OC)cc4c13)c(=O)[nH]c1cc(O)c(OC)cc21
SMILES:COc1ccc(cc1O)-c1c2c(n3ccc4cc(O)c(OC)cc4c13)c(=O)[nH]c1cc(O)c(OC)cc21

Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].

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