BAY-155 | CAS 2163769-52-4 | AnyMole

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HIT218847529

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HIT218847529

HIT ID:HIT218847529
Cas No:2163769-52-4
常用名:BAY-155
IUPAC:2-[2-cyano-4-methyl-5-({2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2,7-diazaspiro[3.5]nonan-7-yl}methyl)-1H-indol-1-yl]acetamide
IUPAC:2-[2-cyano-4-methyl-5-({2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2,7-diazaspiro[3.5]nonan-7-yl}methyl)-1H-indol-1-yl]acetamide
InChI key:KMCCLTBDFVCDLQ-UHFFFAOYSA-N

分子式:C28H28F3N7OS
分子量:567.64
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1c(CN2CCC3(CN(C3)c3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2n(CC(N)=O)c(cc12)C#N
SMILES:Cc1c(CN2CCC3(CN(C3)c3ncnc4sc(CC(F)(F)F)cc34)CC2)ccc2n(CC(N)=O)c(cc12)C#N

BAY-155 is a powerful and selective menin-MLL inhibitor, exhibiting an IC 50 of 8 nM. It significantly down-regulates MEIS1 gene expression while up-regulating CD11b and MNDA genes. BAY-155 also demonstrates anti-proliferative effects in AML/ALL (acute myeloid/lymphoblastic leukemia) models [1].

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供应商
TargetMolSC
规格
货期
3-6月
纯度
-
待询
1

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