Divarasib adipate | GDC-6036 adipate | CAS 2762240-36-6 | AnyMole

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HIT218847895

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HIT218847895

HIT ID:HIT218847895
Cas No:2762240-36-6
常用名:Divarasib adipate
别名:GDC-6036 adipate
IUPAC:1-(4-{7-[6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl]-6-chloro-8-fluoro-2-[(1-methylpyrrolidin-2-yl)methoxy]quinazolin-4-yl}-3-methylpiperazin-1-yl)prop-2-en-1-one; hexanedioic acid
IUPAC:1-(4-{7-[6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl]-6-chloro-8-fluoro-2-[(1-methylpyrrolidin-2-yl)methoxy]quinazolin-4-yl}-3-methylpiperazin-1-yl)prop-2-en-1-one; hexanedioic acid
InChI key:KUWNSHZGOCXVAI-UHFFFAOYSA-N

分子式:C35H42ClF4N7O6
分子量:768.21
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)CCCCC(O)=O.CC1CN(CCN1c1nc(OCC2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C
SMILES:OC(=O)CCCCC(O)=O.CC1CN(CCN1c1nc(OCC2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C

Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].

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TargetMolSC
规格
货期
3-6月
纯度
-
待询
1

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