Name: Gambogic amide
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT218848082
Cas No:286935-60-2
常用名:Gambogic amide
IUPAC:(2Z)-4-[(1S,2S,8R,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0^{2,15}.0^{2,19}.0^{4,13}.0^{6,11}]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enamide
IUPAC:(2Z)-4-[(1S,2S,8R,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0^{2,15}.0^{2,19}.0^{4,13}.0^{6,11}]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enamide
InChI key:NFVXKLYWFCNBCO-FNQWGUOBSA-N

分子式:C38H45NO7
分子量:627.778
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC3([H])C=C4C(=O)c5c(O)c6C=C[C@@](C)(CCC=C(C)C)Oc6c(CC=C(C)C)c5O[C@@]14[C@@](C\C=C(\C)C(N)=O)(OC2(C)C)C3=O
SMILES:[H][C@@]12CC3([H])C=C4C(=O)c5c(O)c6C=C[C@@](C)(CCC=C(C)C)Oc6c(CC=C(C)C)c5O[C@@]14[C@@](C\C=C(\C)C(N)=O)(OC2(C)C)C3=O

Gambogic amide acts as a potent and selective agonist for TrkA, promoting tyrosine phosphorylation and activating downstream signaling pathways such as Akt and MAPK. It specifically binds to the cytoplasmic juxtamembrane domain of the TrkA receptor, stimulating dimerization and activation. The compound demonstrates neuroprotective properties by preventing neuronal cell death caused by glutamate. Additionally, gambogic amide shows enhanced efficacy in a transient middle cerebral artery occlusion model of stroke and may be useful for investigating neurodegenerative diseases and stroke [1].

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