Name: LAH-1
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT218848387
Cas No:3018150-68-7
常用名:LAH-1
IUPAC:N-[3-fluoro-4-({2-[(3-hydroxyazetidine-1-carbonyl)amino]pyridin-4-yl}oxy)phenyl]-1-(4-fluorophenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide
IUPAC:N-[3-fluoro-4-({2-[(3-hydroxyazetidine-1-carbonyl)amino]pyridin-4-yl}oxy)phenyl]-1-(4-fluorophenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide
InChI key:FWLVRTXBVZUMLE-UHFFFAOYSA-N

分子式:C27H22F2N6O5
分子量:548.507
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc(NC(=O)N3CC(O)C3)c2)c(F)c1)-c1ccc(F)cc1
SMILES:Cc1cc(=O)n(nc1C(=O)Nc1ccc(Oc2ccnc(NC(=O)N3CC(O)C3)c2)c(F)c1)-c1ccc(F)cc1

LAH-1, an oral c-Met inhibitor with membrane permeability, demonstrates an IC 50 of 49 nM and exhibits anticancer activities by inducing apoptosis, migration, and invasion [1].

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