Name: Microcolin H
Rating: 5 (10 reviews)

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HIT ID:HIT218848490
Cas No:2408008-21-7
常用名:Microcolin H
IUPAC:(1S,2R)-1-[(2S)-2-[(2R)-N,2-dimethyloctanamido]-4-methylpentanamido]-1-{[(2S)-1-[(2S,4S)-4-hydroxy-2-[(2S)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}propan-2-yl acetate
IUPAC:(1S,2R)-1-[(2S)-2-[(2R)-N,2-dimethyloctanamido]-4-methylpentanamido]-1-{[(2S)-1-[(2S,4S)-4-hydroxy-2-[(2S)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}propan-2-yl acetate
InChI key:VVVUQZUDSPOQAQ-PEYQGHOASA-N

分子式:C38H63N5O9
分子量:733.948
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC[C@@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)OC(C)=O)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C[C@@H](O)C[C@H]1C(=O)N1[C@@H](C)C=CC1=O
SMILES:CCCCCC[C@@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)OC(C)=O)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C[C@@H](O)C[C@H]1C(=O)N1[C@@H](C)C=CC1=O

Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].

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