Name: NEO214
Rating: 5 (10 reviews)

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HIT ID:HIT218848557
Cas No:1361198-80-2
常用名:NEO214
IUPAC:[(4S)-4-(prop-1-en-2-yl)cyclohex-1-en-1-yl]methyl 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxopyrrolidine-1-carboxylate
IUPAC:[(4S)-4-(prop-1-en-2-yl)cyclohex-1-en-1-yl]methyl 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxopyrrolidine-1-carboxylate
InChI key:JDWAOYHBJSFPSD-PSDZMVHGSA-N

分子式:C27H35NO5
分子量:453.579
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(cc1OC1CCCC1)C1CN(C(=O)OCC2=CC[C@H](CC2)C(C)=C)C(=O)C1
SMILES:COc1ccc(cc1OC1CCCC1)C1CN(C(=O)OCC2=CC[C@H](CC2)C(C)=C)C(=O)C1

NEO214, an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and blood-brain barrier (BBB) permeability. It prevents autophagy-lysosome fusion, blocking autophagic flux and triggering glioma cell death via mTOR activation and TFEB (Transcription Factor EB) aggregation. NEO214 inhibition of Macroautophagy/autophagy in glioblastoma cells may overcome chemotherapy resistance in glioblastoma [1].

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