Name: Nipamovir
Rating: 5 (10 reviews)

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HIT ID:HIT218848578
Cas No:2651908-78-8
常用名:Nipamovir
IUPAC:3-({2-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]phenyl}formamido)propanamide
IUPAC:3-({2-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]phenyl}formamido)propanamide
InChI key:VCFXTULPPKLMGT-UHFFFAOYSA-N

分子式:C14H15N5O4S
分子量:349.37
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cn1cnc(c1Sc1ccccc1C(=O)NCCC(N)=O)[N+]([O-])=O
SMILES:Cn1cnc(c1Sc1ccccc1C(=O)NCCC(N)=O)[N+]([O-])=O

Nipamovir is a nitroimidazole prodrug that exhibits antiviral activity comparable to SAMT-247 and NS-1040 in cellular assays and a human ex vivo model of HIV infection, with low toxicity. Nipamovir has EC50 values of 3.64±3.28 and 3.23±2.81 μM for CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, respectively [1].

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