Name: Nur77 modulator 3
Rating: 5 (10 reviews)

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HIT ID:HIT218848610
Cas No:2097787-75-0
常用名:Nur77 modulator 3
IUPAC:3-[(E)-[(1H-indol-3-yl)methylidene]amino]-1-(4-methylphenyl)thiourea
IUPAC:3-[(E)-[(1H-indol-3-yl)methylidene]amino]-1-(4-methylphenyl)thiourea
InChI key:PLURIIVXGBZIRM-YBFXNURJSA-N

分子式:C17H16N4S
分子量:308.4
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc(NC(=S)N\N=C\c2c[nH]c3ccccc23)cc1
SMILES:Cc1ccc(NC(=S)N\N=C\c2c[nH]c3ccccc23)cc1

Nur77 modulator 3 (9e) binds to Nur77 and inhibits TGF-β1-induced α-SMA and COLA1 expression in a Nur77-dependent manner. It induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis [1].

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