Name: PROTAC AR/AR-V7 degrader-1
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT218848782
Cas No:2841308-96-9
常用名:PROTAC AR/AR-V7 degrader-1
IUPAC:4-(3-{2-[(8-fluoroquinolin-5-yl)amino]ethyl}-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
IUPAC:4-(3-{2-[(8-fluoroquinolin-5-yl)amino]ethyl}-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
InChI key:QMRZVTDYXXBISG-UHFFFAOYSA-N

分子式:C24H19F4N5O2
分子量:485.443
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1(C)N(CCNc2ccc(F)c3ncccc23)C(=O)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F
SMILES:CC1(C)N(CCNc2ccc(F)c3ncccc23)C(=O)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F

PROTACAR/AR-V7 degrader-1 (27c) 作为AR与AR-V7的双效PROTAC降解剂，显示出DC50值为2.67 μM和2.64 μM。此外，该化合物具备诱导凋亡的功能。

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