Name: PROTAC AR Degrader-5
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT218848790
Cas No:2703021-51-4
常用名:PROTAC AR Degrader-5
IUPAC:(2S,4R)-1-[(2S)-2-(2-{4-[4-(5-{3-[4-cyano-2-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}pyridin-2-yl)phenoxy]butoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
IUPAC:(2S,4R)-1-[(2S)-2-(2-{4-[4-(5-{3-[4-cyano-2-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}pyridin-2-yl)phenoxy]butoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
InChI key:HEIBMKWAJBMSPY-VTYXGMTLSA-N

分子式:C52H54F4N8O7S2
分子量:1043.17
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(cc2)-c2ccc(cn2)N2C(=S)N(C(=O)C2(C)C)c2ccc(C#N)c(c2F)C(F)(F)F)C(C)(C)C)cc1
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(cc2)-c2ccc(cn2)N2C(=S)N(C(=O)C2(C)C)c2ccc(C#N)c(c2F)C(F)(F)F)C(C)(C)C)cc1

PROTACAR Degrader-5（compound A46）是一种有效的AR PROTAC降解剂，其IC50值为49 nM。该化合物抑制皮脂斑并诱导毛发再生。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~