Name: Thalidomide-azetidine-C-PIP-C-boc
Rating: 5 (10 reviews)

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HIT ID:HIT218849017
Cas No:2589699-87-4
常用名:Thalidomide-azetidine-C-PIP-C-boc
常用名:Thalidomide-azetidine-C-PIP-C-boc
IUPAC:tert-butyl 2-[4-({1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]azetidin-3-yl}methyl)piperazin-1-yl]acetate
IUPAC:tert-butyl 2-[4-({1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]azetidin-3-yl}methyl)piperazin-1-yl]acetate
InChI key:AOGDFEGBFCPWQV-UHFFFAOYSA-N

分子式:C27H35N5O6
分子量:525.606
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(C)OC(=O)CN1CCN(CC2CN(C2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
SMILES:CC(C)(C)OC(=O)CN1CCN(CC2CN(C2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1

Thalidomide-azetidine-C-PIP-C-boc is a conjugate of E3 ligase ligand and linker, comprising Thalidomide and the corresponding linker. As a Cereblon ligand, Thalidomide-azetidine-C-PIP-C-boc recruits CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.

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