Name: W6134
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT218849115
Cas No:2983540-55-0
常用名:W6134
IUPAC:N-(2'-chloro-4'-{2-[4-(ethanesulfonyl)phenyl]acetamido}-[1,1'-biphenyl]-2-yl)prop-2-enamide
IUPAC:N-(2'-chloro-4'-{2-[4-(ethanesulfonyl)phenyl]acetamido}-[1,1'-biphenyl]-2-yl)prop-2-enamide
InChI key:PSNSGPNLXRHGNN-UHFFFAOYSA-N

分子式:C25H23ClN2O4S
分子量:482.98
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(Cl)c2)-c2ccccc2NC(=O)C=C)cc1
SMILES:CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(Cl)c2)-c2ccccc2NC(=O)C=C)cc1

W6134 is a highly potent and selective RORγ covalent inhibitor with an IC50 of 0.21 μM. It exhibits superior activity in inhibiting proliferation and colony formation, and inducing apoptosis, making it useful for cancer research [1].

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