Name: PROTAC STING Degrader-2
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT218849644
Cas No:
常用名:PROTAC STING Degrader-2
IUPAC:4-{[1,1'-biphenyl]-4-amido}-2-(4-fluorobenzenesulfonamido)phenyl 6-{[1-(3-{[3-(3-{[(2S)-1-[(2S,4R)-4-hydroxy-2-{[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}propanamido)propyl]carbamoyl}benzenesulfonyl)-6-oxo-1,6-dihydropyridin-3-yl]formamido}hexanoate
IUPAC:4-{[1,1'-biphenyl]-4-amido}-2-(4-fluorobenzenesulfonamido)phenyl 6-{[1-(3-{[3-(3-{[(2S)-1-[(2S,4R)-4-hydroxy-2-{[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}propanamido)propyl]carbamoyl}benzenesulfonyl)-6-oxo-1,6-dihydropyridin-3-yl]formamido}hexanoate
InChI key:RXNBROLBKMPODG-ABLHSHFVSA-N

分子式:C74H79FN10O15S3
分子量:1463.68
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCC(=O)NCCCNC(=O)c1cccc(c1)S(=O)(=O)n1cc(ccc1=O)C(=O)NCCCCCC(=O)Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
SMILES:C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCC(=O)NCCCNC(=O)c1cccc(c1)S(=O)(=O)n1cc(ccc1=O)C(=O)NCCCCCC(=O)Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

PROTAC STING Degrader-2 是针对 Stimulator of interferon genes (STING) 的蛋白质降解剂，具有DC50为0.53 μM的活性。它通过同时与STING蛋白和E3泛素连接酶共价结合，诱导STING蛋白的降解。该化合物可用于研究STING在自身炎症和自身免疫性疾病中的作用。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~