Name: A11
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT218849727
Cas No:
常用名:A11
别名:ANXA1-derived 11 amino acid–long peptide
别名:ANXA1-derived 11 amino acid–long peptide
IUPAC:(4S)-4-amino-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2R)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-[(carboxymethyl)carbamoyl]pentyl]carbamoyl}-2-hydroxyethyl]carbamoyl}-2-hydroxyethyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}butanoic acid
IUPAC:(4S)-4-amino-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2R)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-[(carboxymethyl)carbamoyl]pentyl]carbamoyl}-2-hydroxyethyl]carbamoyl}-2-hydroxyethyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}butanoic acid
InChI key:SRSGQBYMCAHDHY-CQZPWPCGSA-N

分子式:C53H88N14O19
分子量:1225.366
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O
SMILES:CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O

A11（ANXA1-derived 11 amino acid–long peptide）是一种阻断ANXA1与EphA2相互作用的肽。A11 减少ANXA1与EphA2的结合，提高Cbl（EphA2 的 E3 泛素连接酶）与EphA2的结合。A11 有效降低EphA2水平并显著增加其泛素化，促进EphA2的内化和EphA2与Cbl在鼻咽癌（NPC）细胞中的共定位。A11 可抑制鼻咽癌细胞的增殖、迁移及侵袭，同时抑制血管生成。

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