Name: Cbl-b-IN-7
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT218851502
Cas No:2815221-35-1
常用名:Cbl-b-IN-7
IUPAC:2-(3-{3-[(R)-fluoro(4-methyl-4H-1,2,4-triazol-3-yl)methyl]oxetan-3-yl}phenyl)-6-[(1S)-1-[(1-methylcyclobutyl)amino]ethyl]-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
IUPAC:2-(3-{3-[(R)-fluoro(4-methyl-4H-1,2,4-triazol-3-yl)methyl]oxetan-3-yl}phenyl)-6-[(1S)-1-[(1-methylcyclobutyl)amino]ethyl]-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
InChI key:NJOKETZTARBFPO-XDHUDOTRSA-N

分子式:C29H31F4N5O2
分子量:557.594
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H](NC1(C)CCC1)c1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cccc(c1)C1(COC1)[C@@H](F)c1nncn1C
SMILES:C[C@H](NC1(C)CCC1)c1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cccc(c1)C1(COC1)[C@@H](F)c1nncn1C

Cbl-b-IN-7 (Compound 248)作为针对casitas B系淋巴瘤(Cbl-b)和c-Cbl的抑制剂，其IC50值分别为6.7 nM与5.2 nM。

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