Name: Cbl-b-IN-10
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT218851508
Cas No:2815225-12-6
常用名:Cbl-b-IN-10
IUPAC:2-[3-(ethylamino)-5-{1-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]cyclobutyl}phenyl]-6-{[(1-methylcyclobutyl)amino]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
IUPAC:2-[3-(ethylamino)-5-{1-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]cyclobutyl}phenyl]-6-{[(1-methylcyclobutyl)amino]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one
InChI key:KVHFSZCGFDFVQF-UHFFFAOYSA-N

分子式:C31H37F3N6O
分子量:566.673
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCNc1cc(cc(c1)C1(Cc2nncn2C)CCC1)N1Cc2c(cc(CNC3(C)CCC3)cc2C(F)(F)F)C1=O
SMILES:CCNc1cc(cc(c1)C1(Cc2nncn2C)CCC1)N1Cc2c(cc(CNC3(C)CCC3)cc2C(F)(F)F)C1=O

Cbl-b-IN-10（Compound 463）为针对casitas B系淋巴瘤（Cbl-b）和c-Cbl的抑制剂，其IC50值分别为6.0 nM和3.5 nM。

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