Name: β-Amyloid (18-28)
Rating: 5 (10 reviews)

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HIT ID:HIT218851946
Cas No:112163-49-2
常用名:β-Amyloid (18-28)
别名:β淀粉样蛋白片段, β-Amyloid 18-28, Beta-淀粉样蛋白片段
IUPAC:(2S)-6-amino-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-phenylpropanamido]-3-phenylpropanamido]propanamido]-4-carboxybutanamido]-3-carboxypropanamido]-3-methylbutanamido]acetamido}-3-hydroxypropanamido]-3-carbamoylpropanamido]hexanoic acid
IUPAC:(2S)-6-amino-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-phenylpropanamido]-3-phenylpropanamido]propanamido]-4-carboxybutanamido]-3-carboxypropanamido]-3-methylbutanamido]acetamido}-3-hydroxypropanamido]-3-carbamoylpropanamido]hexanoic acid
InChI key:OQGBMWCKAXYTON-UWDGXVTOSA-N

分子式:C55H81N13O18
分子量:1212.326
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O
SMILES:CC(C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O

Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice. These peptides have only amino acid residues VFF at position 18 to 20 in common, suggesting the amnestic effect of the triad.

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