Name: Pep2m, myristoylated
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT218852023
Cas No:1423381-07-0
常用名:Pep2m, myristoylated
IUPAC:(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-tetradecanamidohexanamido]-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]hexanamido]-3-methylbutanamido]propanamido]hexanamido]-3-carbamoylpropanamido]propanamido]-4-carbamoylbutanoic acid
IUPAC:(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-tetradecanamidohexanamido]-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]hexanamido]-3-methylbutanamido]propanamido]hexanamido]-3-carbamoylpropanamido]propanamido]-4-carbamoylbutanoic acid
InChI key:WOHZPGNQJGMOFO-KJNWLHRWSA-N

分子式:C63H118N18O14S
分子量:1383.81
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(O)=O
SMILES:CCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(O)=O

Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression.

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