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  3. HIT218852034
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HIT218852034
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HIT218852034
  • HIT ID:HIT218852034
  • Cas No:592517-80-1
  • 常用名:11R-VIVIT
  • 别名:NFAT inhibitor, Cell Permeable
  • IUPAC:(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-{2-[(2S,3R)-2-[(2S,3S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{[(2S)-1-{2-[(2S)-2-[(2S)-2-[2-(2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]acetamido}acetamido)acetamido]-4-(methylsulfanyl)butanamido]propanamido]acetyl}pyrrolidin-2-yl]formamido}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-methylbutanamido]-3-methylpentanamido]-3-methylbutanamido]-3-methylpentanamido]-3-hydroxybutanamido]acetyl}pyrrolidin-2-yl]formamido}-3-(1H-imidazol-5-yl)propanamido]-4-carboxybutanamido]pentanedioic acid
    IUPAC:(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-{2-[(2S,3R)-2-[(2S,3S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{[(2S)-1-{2-[(2S)-2-[(2S)-2-[2-(2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]acetamido}acetamido)acetamido]-4-(methylsulfanyl)butanamido]propanamido]acetyl}pyrrolidin-2-yl]formamido}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-methylbutanamido]-3-methylpentanamido]-3-methylbutanamido]-3-methylpentanamido]-3-hydroxybutanamido]acetyl}pyrrolidin-2-yl]formamido}-3-(1H-imidazol-5-yl)propanamido]-4-carboxybutanamido]pentanedioic acid
  • InChI key:VNTCWMOQGXMIQP-PIQGMSCVSA-N
  • 分子式:C147H259N67O36S
  • 分子量:3573.18
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
    SMILES:CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
  • NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 9,480.00
    1

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