Name: SAX-187 hydrochloride
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT218852106
Cas No:554403-08-6
常用名:SAX-187 hydrochloride
IUPAC:2-[1-({6-chloroimidazo[2,1-b][1,3]thiazol-5-yl}sulfonyl)-1H-indol-3-yl]ethan-1-amine hydrochloride
IUPAC:2-[1-({6-chloroimidazo[2,1-b][1,3]thiazol-5-yl}sulfonyl)-1H-indol-3-yl]ethan-1-amine hydrochloride
InChI key:YWNBHKWSECANPP-UHFFFAOYSA-N

分子式:C15H14Cl2N4O2S2
分子量:417.32
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
SMILES:Cl.NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12

SAX-187 hydrochloride is a potent and selective 5-HT6 receptor agonist. SAX-187 hydrochloride possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (SAX-187 hydrochloride: EC50=6.6 nM, Emax=93%). In the rat frontal cortex, acute administration of SAX-187 hydrochloride (3-30 mg/kg, subcutaneous (s.c.)) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~